Applications

• Protein A alternative for MAb Purification
  Natrix Separations Inc. has developed a new generation of chromatographic media with dynamic binding capacity and throughput that exceeds best in class resins and membranes. This poster reviews the exploration of the adseptTM Weak C-type cation exchange membrane as an alternative to Protein A for the purification of monoclonal antibodies (MAbs).
  (Click title to download PDF)
  
  
• Principles of ion-exchange chromatography for buffer optimization
  Natrix has developed this guide to provide Natrix membrane users with background information to enable the user to select the correct type of salt or buffer, in the correct concentrations, to optimize their separations.
  (Click title to download PDF)
  
  
• Single Step Clarification & Capture of a Recombinant Protein from E. coli Osmotic Shock by Crossflow Chromatography,
  (Click title to download PDF)
  
  
• Ion Exchange membrane chemical compatibility.
  (Click title to download PDF)
  
  
• IMAC Ni membrane chemical compatibility
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References

• A Single-Use Purification Platform for Monoclonal Antibodies.
  Presented by Percivia at the 2010 IBC Single Use Meeting in La Jolla in June of 2010. Natrix Separations Weak C chromatography membrane was selected for the capture step in a monoclonal antibody purification.
  (Click title to download PDF)
  
  
• Preliminary report on the ability of Natrix Separations anion exchange membrane to remove virus. Study indicates a 7 log reduction may be possible. (print on 11"x17").
  (Click title to download PDF)

Demonstration

• Natrix Separations 25mm Syringe Column Demonstration.
  See the ease of use and binding capacity of the 25mm syringe columns in this brief video. This clip presents the 25 mm S Cation exchange syringe column to illustrate simplicity and ease of use with common a laboratory dye.
  (Click title to view demonstration video)