How Natrix Technology Benefits Downstream Processing

Binding Capacity plus high flowrates results in process productivity gains which enable:

• Achieve required production scale capacity in a much smaller package
   
• Reduce physical size and footprint (60%-80% smaller footprint)
   
• Eliminate large, fixed glass columns, which are capital intensive, limited in utility and vulnerable to catastrophic failure
  • No packing of columns
  • No storage of resin
  • No storing of packed columns
     
• Smaller format introduces flexibility, modularity… Production facility is transformed from dedicated, single-product to a simplified, flexible, universal plant that can handle multiple products at range of scales
   
• Reduced size means less buffer use:  80% reduction in water, chemicals for buffer.  80% less disposal too
  • For a new facility, this can reduce the size of  the buffer prep area and  greatly simplify the required infrastructure
     
  • Reduced labor 
     

Single-Use Format enables:

• Elimination of cleaning, sanitizing, validation and storage of conventional columns. (reduction in Water for Injection by 65-80%)
   
• Simplified regulatory compliance (no cleaning validation of columns)
   
• Fast batch-to-batch turnover and product-to-product turnover
   
• Complete single-use facilities are now feasible and practical
   
• Labor savings, cleaning materials savings, storage savings, cost of capital savings