How Natrix HD Membranes Work

How Natrix HD Membranes Work

The unique composition of Natrix HD Membranes brings together a number of novel features that combine to create a major leap forward in chromatographic efficiency:

 

High functional binding group density

Natrix HD Membranes feature a hydrogel that is comprised of up to 95% functional monomer, making the hydrogel structure itself functional. As a result, the membranes are uniformly and densely saturated with binding sites.

As an example, the dynamic binding capacity (BSA) of Natrix HD-Q Membranes far exceeds other commercially available membranes and resin products. 

 

 




 

Functional groups are readily accessible

With Natrix HD membranes, a feedstream passes through a network of interconnected pores (nominal pore size 0.4 μm) where every contact surface is loaded with functional binding groups. The advective mass transfer in the pore network enables high binding performance at much higher flow rates than diffusion based resins.

 

Multi-Point molecular binding

With conventional chromatography membranes and resins, proteins are often captured by a single functional charge. With Natrix HD’s structure and high functional group density, the close proximity of binding sites allows for multi-point ionic bonding so that protein molecules can be secured by multiple charge points simultaneously. This results in a more robust bond, which can overcome difficult operating conditions, including salt, pH and even phosphate.